The study of epistemology attempts to separate what we know from what we merely believe. This distinction can take on various forms, but generally the things we "know" without equivocation are rather few and are not very interesting things, if anything at all. We know of existence - of ourselves, of others, of objects. But when it comes to relationships between things that exist - and specifically, interactions between things that exist through time and space - we find that there is very little that is definite. How can we know, without a doubt, that the laws of gravity and the natural world will hold in the future, that the sun will rise tomorrow? First, let us put aside the nature of knowledge itself to revisit later. It will be essential to fully define terms for use in later constructs.
I prefer to make a clear distinction between science and (for lack of a better term) non-science. Here I use "science" to mean the study of any process in time, space, or mental construct which has a deterministic outcome - or, to be more precise with terms, the study of deterministic processes. This does not mean that the outcome was infallibly predictable at a time prior to the interaction. In fact, it does not mean that the outcome was even observable to us. It
simply means that the interaction resulted in an outcome which conceivably could have been predicted with certainty.